Let's say, you already have a resource with the rule of work.
For example, daily rental from 9:00 AM — 6:00 PM.
First, create another rule of work to determine the periods when your price option will be unavailable.
Read how to create a rule of work here
Click on the intersection of the created rule and the price option, which should be unavailable.
In the settings form opened, click Disabled.
And save it.
Look at the example in action, where we have turned off Tariff B on weekends: